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Betahistine
An Israeli physician may have stumbled on a pill that treats obesity, without side effects, and one that's been known about for more than 60 years. Upon learning that blocking the brain's histamine-1 receptor causes weight gain, Tel-Aviv based nutrition expert Nir Barak went looking for a drug that would stimulate that receptor. He found Betahistine, which has been used to treat vertigo since the 1940s. Stimulating the histamine-1 reactor appears to reduce the craving not only for food in general but for fatty foods in particular. Less fat usually means less cholesterol, so Obecure is also targeting the $28 billion market for cholesterol reducing drugs. Betahistine was taken off the U.S. market in 1970 when the FDA began scrutinizing drugs more rigorously and demanded more clinical trials. Betahistine's manufacturer, Unimed, never complied. A generic version is still sold in Europe, but the compound is no longer under U.S. patent protection. Bio-light Isreal Life Science Investments has funded all clinical development trials for Mr. Barak's new company, Obecure. Barak succeeded in getting weight-loss expert Robert Kushner to conduct a double-blind clinical trial. Final results are not in yet, but Kushner claims that participants lost up to 12% of their body weight. Participants said that it wasn't hard, they weren't thinking about food, and they were content. It's not uncommon to see a drug shifting its indication once it's been put to use. Betahistine may soon become the most famous example.
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