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Leptin
Preliminary results from early studies on the use of daily injections of genetically engineered leptin are reporting weight loss among some genetically obese subjects. Higher doses may be needed for higher weights. The most common side effects were pain at the injection site and headache. There appear to be no significant adverse effects on major organs, including the heart, liver, kidney, central nervous system, or gastrointestinal tract. It also does not appear to affect insulin levels, a previous concern. According to the Wall Street Journal, genomics-based obesity drugs are being tested in human trials. After years of analyzing the human genome, scientists at Millennium Pharmaceuticals say they have finally found a gem; an obesity drug that works by changing metabolism. Traditionally, obesity drugs have been appetite suppressants, which often come with severe side effects. The new drug, co-developed with Abbott Laboratories of Chicago, is part of a new class of medications that seek to alter metabolism. Known by the name MLN4760, the drug is based on the discovery of a gene that provides instructions for the production of an enzyme that scientists believe helps prompt the body to store fat. The drug doesn’t act directly on the gene, but rather inhibits the enzyme’s action- theoretically prompting the body to burn fat, rather than store it. It is still too early to tell if the drug will be a success. Most early-stage drugs in fact fail.
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Overview | Betahistine | Didrex | Diethylproprion | Leptin | Meridia Phendimetrazine | Phentermine | Rimonabant | Xenical and Alli |
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